ºÃÔÉÑ· ¤ÍÊâÁ«ÙµÔ¤ÍÅ ¨Ó¡Ñ´
·ÕèÍÂÙè : àÅ¢·Õè 104 ¶¹¹Êó¤Á¹ì á¢Ç§Êաѹ ࢵ´Í¹àÁ×ͧ ¡·Á.10210
àºÍÃìâ·Ã : 02-929 7512 â·ÃÊÒà : 02-929 7513 Á×Ͷ×Í : 089-4770870
ÍÕàÁÅ : cosmoceutical.co.th@gmail.com
àÇçºä«µì : www.cosmoceutical.co.th
¼ÅÔµÀѳ±ì |
໻䷴ì Å´ÃÔéÇÃÍ ÊÔÇ ½éÒ ¡ÃÐ ¨Ø´´èÒ§´Ó www.cosmoceutical.co.th ¤ÃÕÁºÓÃا¼ÔÇ˹éÒ ¤ØéÁ¤èÒ ÃҤҤسÀÒ¾ à»»ä·´ì ¡Òä鹾º AHA (Alphahydroxy acid) áÅÐ Retinol 㹵͹µé¹¤ÃÔʵìȵÇÃÃÉ·Õè 19 ¶×Íà»ç¹¡Òä鹾º·ÕèÊӤѵèÍ¡ÒþѲ¹ÒÍصÊÒË¡ÃÃÁà¤Ã×èͧÊÓÍÒ§ ·ÓãËé¡ÒÃãªéà¤Ã×èͧÊÓÍÒ§ÁÔãªèà¾Õ§à¾×èÍ»¡»éͧËÃ×Íà¾ÔèÁ¤ÇÒÁÊǧÒÁà·èÒ¹Ñé¹ áµèÊÒÁÒö·ÓãËéà¡Ô´¡ÒÃà»ÅÕè¹á»Å§µèͺÃÔàdz·ÕèãªéãËéàËç¹¼Åä´éÍÂèÒ§ÁÕ»ÃÐÊÔ·¸ÔÀÒ¾ ¨Ö§à¡Ô´¤ÓÇèÒ Cosmeceutical ãËéà»ç¹·ÕèÃÙé¨Ñ¡ãªé¡Ñ¹ÍÂèÒ§¡ÇéÒ§¢ÇÒ§
ÁÕÊÒÃÊÓ¤Ñà¡Ô´¢Öé¹ÁÒ¡ÁÒÂËÅÒª¹Ô´ ·Ñ駷ÕèÊ¡Ñ´¨Ò¡¾×ª¾Ãó¸ÃÃÁªÒµÔ Êѧà¤ÃÒÐËì¨Ò¡Ëéͧ»®ÔºÑµÔ¡Ò÷ҧà¤ÁÕ ãËéàÅ×Í¡ãªéãËéàËÁÒСѺ¼ÅÔµÀѳ±ìµèÒ§ª¹Ô´ à¾×èÍËÇѧ¼ÅÅ´ÍÒ¡Òà ÃÑ¡ÉÒ¤ÇÒÁ¼Ô´»¡µÔ·Õèà¡Ô´¢Öé¹ ÁÕ¡Ò÷´Åͧ¡è͹¹ÓÁÒãªé â´ÂÇÔ¸Õ·Óã¹Ëéͧ·´Åͧãªéà«ÅÅì¨ÓÅͧ (invitro) ËÃ×Í·´Åͧãªé¨ÃÔ§â´ÂÍÒÊÒÊÁѤà (invivo) à»ÃÕºà·Õº¼Å¡è͹áÅÐËÅѧ¡ÒÃãªé¼ÅÔµÀѳ±ì áÅéǹÓÁÒ»ÃÐÁÇżÅãËéàË繨ÃÔ§â´Â¡ÒÃãªéµÑÇàÅ¢Ê¶ÔµÔ ÊÒáÅØèÁ·ÕèÁÕº·ºÒ·Áҡ㹡ÒÃãªéà»ç¹ÊÒÃÊÓ¤Ñà¾×èͼÅÔµ Cosmeceutical ¤×ÍÊÒÃ໻䷴ì
໻䷴ìÁÕ¢éÍ´Õ¡ÇèÒ¡ÒÃãªé AHA áÅÐ Retinol ´éÇÂà˵ؼŷÕèÊӤѤ×Íãªéä´é¼Å´Õã¹»ÃÔÁÒ³¹éÍ äÁèÁռšèÍÃФÒÂà¤×ͧµèͺÃÔàdz·Õèãªé »ÃÐÊÔ·¸ÔÀÒ¾¢Í§à»»ä·´ì¢Ö鹡Ѻ¤ÇÒÁÂÒǢͧÊÒÂâ«è¡Ã´ÍÐÁÔâ¹ ÅӴѺª¹Ô´¡Ã´ÍÐÁÔâ¹·ÕèàÃÕ§µè͡ѹº¹ÊÒÂâ«è ·ÓãËéÁÕ໻䷴ìãËéàÅ×Í¡ãªéä´éÁÒ¡ÁÒµÒÁÇѵ¶Ø»ÃÐʧ¤ì ä´éÍÂèҧ੾ÒÐà¨ÒШ§ àªè¹ Glycyl-Histidyl-Lysine ·Ó˹éÒ·Õè¡ÃеØ鹡ÒÃÊÃéÒ§¤ÍÅÅÒਹã¹à«ÅÅì fibroblast Glycyl-Lysyl-Histidine ·Ó˹éÒ·Õè¡ÃеØ鹡ÒÃÊÅÒµÑǢͧä¢Áѹã¹à«ÅÅì adipocyte ÊÒÁÒö¨Óṡ˹éÒ·Õè¢Í§à»»ä·´ìµÒÁ¢ºÇ¹¡Ò÷Õè໻䷴ìà¢éÒä»ÁÕº·ºÒ·µèÍà«ÅÅìä´é´Ñ§¹Õé
1) à»ç¹ªÕÇâÁàÅ¡ØÅ·ÕèÊè§ÊÑÒ³ãËéà¡Ô´»®Ô¡ÔÃÔÂÒªÕÇà¤ÁÕ·Õè¨Óà»ç¹¢Í§à«ÅÅìã¹µÓá˹觵èÒ§ æ
·Õè¼ÔÇ˹ѧ ËÑÇ㨠ÊÁͧ Ãѧä¢è à»ç¹µé¹
2) ¡ÃеØ鹡ÒÃÊÃéÒ§ macromolecules àªè¹ collagen elastin fibronectin
3) ÂѺÂÑ駢ºÇ¹¡ÒÃàÁµÒºÍÅÔ«ÖÁ·ÓãËéà¡Ô´¡ÒÃÅ´¡ÒÃÊÃéÒ§àÁÅÒ¹Ô¹ à¾ÔèÁ¡ÒÃÂèÍÂÊÅÒÂä¢Áѹ à»ç¹µé¹
4) à¾ÔèÁ¡Åä¡¡Òûéͧ¡Ñ¹µÑÇàͧ¢Í§à«ÅÅì
¨Ð¾ºÇèÒ໻䷴ìÁÕÍÔ·¸Ô¾ÅµèÍà«ÅÅìµèÒ§æÃèÒ§¡ÒÂÁÒ¡ÁÒ ¼Åâ´ÂµÃ§µèÍà«ÅÅì¼ÔÇÊÒÁÒöÊÃØ»ä´é¤×Í
1) ¡ÃеØ鹡ÒÃÊÃéÒ§ macromoleculeà¾ÔèÁ¡ÒÃÊÃéÒ§ collagen
2) ¤Çº¤ØÁ¡ÒÃàÊ×èÍÁÊÀÒ¾¢Í§ collagen
3) ¤Çº¤ØÁ¡Ò÷ӧҹ¢Í§àÍç¹ä«Áì·Õè·Ó˹éÒ·Õèà»ç¹ antioxidant
4) »ÃѺ»Ãا«èÍÁá«Á¡ÒÃÊÖ¡ËÃͧ͢à«ÅÅì
5) Å´¡ÒÃÊÃéÒ§àÁÅÒ¹Ô¹·Õèà¡Ô¹¨Óà»ç¹ ·ÓãËéÊÕ¼ÔÇÊÁèÓàÊÁÍ
6) »éͧ¡Ñ¹¡ÒÃà¨ÃԢͧàª×éÍẤ·ÕàÃÕÂ
¡ÒÃàÅ×Í¡ãªé໻䷴ì¢Ö鹡ѺÇѵ¶Ø»ÃÐʧ¤ì·Õèµéͧ¡ÒÃÇèÒ ¨ÐàÅ×Í¡ãªéãËéà¡Ô´¼ÅÍÂèÒ§äà ÁÕãËéàÅ×Í¡à¾×èÍÅ´ÃÔéÇÃÍ »ÅÙ¡¼Á ·ÓãËé¼ÔÇÊÕà¢éÁÊÇ ·ÓãËé¼ÔÇ¢ÒÇÊÇ Ŵ¡ÒÃà¡Ô´¼ÔÇà»Å×Í¡ÊéÁ à«ÅÅÙäÅµì ¡ÃеØ鹡ÒÃÊÃéÒ§ stem cell »Ñ¨¨ØºÑ¹ÁÕ¾º¡ÒÃãªé໻䷴ìã¹¼ÅÔµÀѳ±ìËÅÒ¡ËÅÒª¹Ô´ àªè¹¤ÃÕÁ·Ò»Ò¡ ¤ÃÕÁ·Ò¶Ø§ãµéµÒ ¤ÃÕÁ·ÒÃͺµÒÅ´ÃͤÅéÓ´Ó à»»ä·´ì·Õè¹ÓÁÒãªéà¾×èÍ·ÓãËé¼ÔÇ¢ÒÇÊÇ·Õ辺㹼ÅÔµÀѳ±ì·ÕèÁÕ¢ÒÂã¹µÅÒ´àªè¹
1) Oligopeptide-34
·Ó˹éÒ·ÕèÅ´¡ÒÃÊÃéÒ§àÁÅÒ¹Ô¹â´ÂÅ´¡Ò÷ӧҹ¢Í§àÍç¹ä«Áìä·âëÔà¹Ê Å´¡Òâ¹ÂéÒÂàÁÅÒ¹Ô¹·Õè¼ÅÔµâ´Âmelanocyte ä»Âѧà«ÅÅì¼ÔǪÑ鹹͡ keratinocyte Å´¡ÒÃÍÑ¡àʺâ´ÂÅ´¡ÒÃÊÃéÒ§ T cell áÅÐÅ´¡ÒÃÊÃéÒ§ TH1 «Öè§à»ç¹proinflammation cytokine
2) Diaminopropionyl Tripeptide-33
·Ó˹éÒ·Õè»éͧ¡Ñ¹à«ÅÅì¼ÔǨҡ¡Ò÷ÓÅÒÂâ´ÂÃѧÊÕÂÙÇÕ Å´¡ÒÃà¡Ô´ Reactive Carbonyl Species ÊÃéÒ§àÊÃÔÁ¡ÒëèÍÁá«Á DNA ·ÕèàÊÕÂËÒ¨ҡ¡Ò÷ÓÅÒÂâ´ÂÃѧÊÕÂÙÇÕ à¾ÔèÁ»ÃÐÊÔ·¸ÔÀÒ¾¢Í§ DNA 㹡Òû¡»éͧµ¹àͧ¨Ò¡ÁÅÀÒÇÐ
3) Palmitoyl Tripeptide-5 ·Ó˹éÒ·Õè»éͧ¡Ñ¹áÅÐàÊÃÔÁÊÃéÒ§¤ÍÅÅÒਹâ´Â¡ÒáÃеØé¹ TGF-b Å´¡ÒÃà¡Ô´ÃÔéÇÃÍÂ
4) Pentapeptide-3 Å´ÃÔéÇÃÍÂâ´Â¡ÒÃÅ´¡Ò÷ӧҹ¢Í§ Acetylcholine·Õèà«ÅÅì¼ÔÇ
5) Oligopeptide-68 àÃ觡Ò÷ÓÅÒ MITF (Microphtalmia-associated transcription factor) Tyrosinase, TRP-1, TRP-2 «Öè§à»ç¹â»ÃµÕ¹·Õè¤Çº¤ØÁ¡ÒÃÊÃéÒ§àÁÅÒ¹Ô¹
¼Ùé¼ÅÔµÊÒÁÒöàÅ×Í¡ÊÃéҧ໻䷴ì¢Öé¹ÁÒãªéä´éÍÂèÒ§äÁèÁÕ¢éͨӡѴ áµè¼ÅµèÍà«ÅÅì¼ÔÇÁÔä´é¢Ö鹡Ѻª¹Ô´¢Í§à»»ä·´ìà¾Õ§ÍÂèÒ§à´ÕÂÇ Âѧ¢Ö鹡Ѻ»ÃÐÊÔ·¸ÔÀÒ¾¢Í§¼ÅÔµÀѳ±ìÇèÒ¨ÐÊÒÁÒö¹ÓÊè§à»»ä·´ìà¢éÒÊÙèà«ÅÅì¼ÔÇä´éÍÂèÒ§äà ¨Ö§à»ç¹¤ÇÒÁ·éÒ·Ò·Õè¹Óä»ÊÙè¡ÒÃàÃÕ¹ÃÙéà¾×è;Ѳ¹ÒÊÃéÒ§¼ÅÔµÀѳ±ìÍÂèÒ§µèÍà¹×èͧ â´ÂºØ¤¤Åҡ÷Õèà¡ÕèÂÇ¢éͧ áÅÐÁÕÃÒ§ÇÑÅà»ç¹¼ÅÊÓàÃ稷ҧ´éÒ¹¡ÒõÅÒ´à»ç¹¤èҵͺ᷹
¢Í¢Íº¤Ø³ ÀÒ¾¨Ò¡ÍÔ¹à·ÍÃìà¹çµ |
àÃÕ¹ÃÙéàÃ×èͧ¼ÔÇ